Pharmaceutical medicine is a medical discipline concerned with the discovery, evaluation, registration, monitoring and clinical aspects of pharmaceutical development. Developing projects for oral insulin is the most appropriate example of pharmaceutical medicine. For the last 10 years, our STEM Science Center invested our passion for developing an oral insulin formulation. Among many oral insulin technologies, searching for penetration promotors and nano-particles has been our major projects. Last year, we did a study of oral insulin using silver nanoparticle. Its data was presented for the Annual Meeting of the American Association of Pharmaceutical Scientists.
Globally, approximately 500 million patients are diagnosed as diabetes patients. Including the large population of the patients, diabetes has been listed as the leading cause of death every year in Korea and the United States. The heart failure, vision loss, and kidney failure are among the multiple complications from diabetes. Until today, insulin should be injected intramuscularly, and subcutaneously. These injection therapies initiate many serious problems such as localized hypoglycemia and hyperinsulinemia.
Alternate route delivery of insulin has been recognized to be a patient-compliant choice that favorably replaces the invasive injection delivery with minimal side-effects. However, many challenging obstacles toward the development of oral insulin are still high, since insulin should be absorbed through the human digestive organs. The low absorption through the gastrointestinal epithelial membrane is one of the major barriers to win over. High enzyme activities exist along the GI tracts.
In this study, each of the barriers might be examined to promote insulin delivery by monitoring blood glucose after the oral administration of the formulation. The application of gold nanoparticles might enhance the molecule’s permeability at tight junction. These mechanisms have been applied for more advanced studies. And, various penetration promotors have been identified from our laboratory and data has been published annually.
The study has been carried out with our staff and students here with Align Biosciences, LLC located at New York Medical College, Valhalla, NY.
Many other projects are under investigation. Please contact our staff when you have any question.